Microneedling for Skin and Hair Rejuvenation: Evidence-Based Benefits and Advanced Combinations

Microneedling, also known as collagen induction therapy, is a popular, evidence-based aesthetic treatment used to improve skin texture, reduce scarring, and stimulate hair growth. By creating controlled micro-injuries in the skin or scalp, microneedling activates the body’s natural healing process, triggering the production of collagen, elastin, and other regenerative factors.

In this article, we explore how microneedling works, its benefits as a standalone treatment, and how results can be enhanced when combined with platelet-rich plasma (PRP) or exosomes. We also review its use in treating both facial skin concerns and hair loss, based on current clinical research.

What Is Microneedling?

Microneedling involves the use of fine needles to puncture the skin at controlled depths, creating microscopic channels that stimulate tissue regeneration. These micro-injuries activate fibroblasts and lead to increased production of type I and III collagen, elastin, and glycosaminoglycans.

Over a series of sessions, this collagen induction therapy improves the appearance of:

• Fine lines and wrinkles

• Acne scars and post-inflammatory hyperpigmentation

• Stretch marks and enlarged pores

• Skin laxity and uneven texture

Microneedling is safe for most skin types and can be customised by adjusting the depth, needle size, and treatment frequency.

Microneedling with PRP: Natural Growth Factor Boost

Combining microneedling with platelet-rich plasma (PRP) enhances its regenerative effects. PRP is derived from the patient’s own blood and contains a high concentration of growth factors, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-β).

When applied after microneedling, PRP penetrates more effectively through the microchannels and accelerates the healing process. It enhances collagen production, reduces downtime, and improves skin tone and firmness. This combination is commonly used for:

• Acne scars

• Periorbital rejuvenation (under-eye area)

• Skin tightening and pigmentation correction

In hair loss, especially androgenetic alopecia, microneedling with PRP has shown superior results compared to PRP injections alone. The technique improves follicle stimulation, prolongs the hair growth (anagen) phase, and supports angiogenesis around hair bulbs.

Microneedling with Exosomes:

Exosome therapy is a newer addition to regenerative aesthetics. Exosomes are tiny extracellular vesicles involved in cell signalling and repair.

Used in conjunction with microneedling, exosomes enhance the skin’s regenerative environment by:

• Reducing inflammation

• Stimulating collagen and elastin synthesis

• Promoting skin hydration and even tone

Microneedling improves exosome absorption by creating direct access to the dermal layer. Clinical studies suggest this combination supports faster healing, smoother skin texture, and may improve outcomes in patients with sensitive or ageing skin.

Exosomes also show promise in promoting hair regrowth by activating dermal papilla cells and stimulating follicle regeneration. This makes them a valuable addition to microneedling protocols for hair restoration.

Microneedling for Hair Loss: Effective and Minimally Invasive

Microneedling for hair loss is an established treatment that improves blood flow, reduces perifollicular inflammation, and stimulates growth factors essential for hair regeneration.

This treatment is used alone or combined with PRP or Exosomes.

Microneedling enhances the delivery of active ingredients through the scalp and may reactivate dormant follicles. Patients with male or female pattern hair loss often see improved hair density, thickness, and scalp coverage with consistent treatment.

Why Microneedling Remains a Key Tool in Regenerative Aesthetics

Microneedling is a powerful, non-surgical procedure that supports both skin and hair rejuvenation. As a standalone treatment, it induces collagen and improves skin quality. When combined with PRP or exosomes, it offers enhanced outcomes, shorter recovery, and longer-lasting results.

Whether you are looking to improve scarring, address signs of ageing, or treat hair thinning, microneedling- particularly when personalised offers a medically backed, minimally invasive solution.

References

1. Li Y, Xu Y, Luo Y, et al. The potential of microneedling therapy in hair loss treatment. J Cosmet Dermatol. 2021;20(2):485–491. PMID: 33538106

2. Park KY, Kim HK, Kim BJ. The efficacy and safety of microneedling combined with growth factor serum for facial rejuvenation. Dermatol Surg. 2023;49(5):540–546. PMID: 38509316

3. Kwon HH, Park MY, et al. Microneedling and exosomes: a new synergistic approach. Skin Res Technol. 2023. PMID: 36074433

4. Hsiao JL, et al. Microneedling and Platelet-Rich Plasma in Acne Scarring: A Clinical Update. J Am Acad Dermatol. 2022. https://www.sciencedirect.com/science/article/pii/S1064740622000293

5. Pourang A, et al. Exosome-based skin rejuvenation: mechanisms and clinical prospects. Regen Med. 2023;18(3):145–156. https://www-tandfonline-com.libproxy.ucl.ac.uk/doi/pdf/10.2217/rme-2022-0134

6. Ahn CS, et al. Scalp microneedling with PRP for alopecia: clinical outcomes and dermoscopic findings. Int J Dermatol. 2022;61(12):1570–1576. PMID: 36407242

7. Zarei M, et al. Clinical application of mesenchymal stem cell-derived exosomes in regenerative dermatology. Cells. 2024;13(1):120. https://pmc.ncbi.nlm.nih.gov/articles/PMC11174266/